Tertiary lymphoid structure-related immune infiltrates in NSCLC tumor lesions correlate with low tumor-reactivity of TIL products

Author:

Castenmiller Suzanne M.12,Kanagasabesan Nandhini12,Guislain Aurélie12,Nicolet Benoît P.12,van Loenen Marleen M.1,Monkhorst Kim3,Veenhof Alexander A.F.A.4,Smit Egbert F.56,Hartemink Koen J.4,Haanen John B.A.G.789,de Groot Rosa110,Wolkers Monika C.12ORCID

Affiliation:

1. Sanquin Blood Supply, Division Research Immunotherapy, and Landsteiner Laboratory and Department of Experimental Immunology, Amsterdam University Medical Center, Amsterdam, Netherlands

2. Oncode Institute, Utrecht, The Netherlands

3. Department of Pathology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital (NKI-AvL), Amsterdam, The Netherlands

4. Department of Surgery, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital (NKI-AvL), Amsterdam, The Netherlands

5. Department of Thoracic Oncology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital (NKI-AvL), Amsterdam, The Netherlands

6. Department of Pulmonology, Leiden University Medical Center (LUMC), Leiden, The Netherlands

7. Division of Medical Oncology and Division of Molecular Oncology and Immunology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital (NKI-AvL), Amsterdam, The Netherlands

8. Department of Medical Oncology, Leiden University Medical Center (LUMC), Leiden, The Netherlands

9. Head of Melanoma Clinic, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland

10. Department of Hematology, LUMC, Leiden, The Netherlands

Funder

intramural Sanquin research funds

Oncode Institute

Publisher

Informa UK Limited

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