Vectorization in an oncolytic vaccinia virus of an antibody, a Fab and a scFv against programmed cell death -1 (PD-1) allows their intratumoral delivery and an improved tumor-growth inhibition

Author:

Kleinpeter Patricia1,Fend Laetitia12,Thioudellet Christine1,Geist Michel1,Sfrontato Nathalie1,Koerper Véronique1,Fahrner Catherine1,Schmitt Doris1,Gantzer Murielle1,Remy-Ziller Christelle1,Brandely Renée1,Villeval Dominique1,Rittner Karola1,Silvestre Nathalie1,Erbs Philippe1,Zitvogel Laurence23456,Quéméneur Eric1,Préville Xavier1,Marchand Jean-Baptiste1

Affiliation:

1. Transgene S.A., Illkirch-Graffenstaden, France

2. Institut Gustave Roussy Cancer Campus (GRCC), Villejuif, France

3. INSERM U1015, GRCC, Villejuif, France

4. Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 1418, GRCC, Villejuif, France

5. University of Paris Sud XI, Kremlin Bicêtre, France

6. Department of Immuno-Oncology, GRCC, Villejuif, France

Publisher

Informa UK Limited

Subject

Oncology,Immunology,Immunology and Allergy

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