Safety and Immunogenicity of a novel three-dose recombinant nanoparticle rabies G protein vaccine administered as simulated post exposure immunization: A randomized, comparator controlled, multicenter, phase III clinical study

Author:

H S Ravish1,Khobragade Akash2,Satapathy Durga3,Gupta Monica4,Kumar Surendra5,Bhomia Vinay6,V Ramasubramanian7,Desai Maharshi8,Agrawal Ashok Dilipkumar9ORCID

Affiliation:

1. Department of Community Medicine, Kempegowda Institute of Medical Science, Bengaluru, India

2. Department of Pharmacology, J J Hospital Byculla, Mumbai, India

3. Department of Community Medicine, VSS Institute of Medical Science and Research, Sambalpur, India

4. Consultant Physician, Samvedna Hospital, Varanasi, India

5. Department of Community Medicine, S P Medical College and A.G Hospitals, Bikaner, India

6. Consultant Physician, Sanjivani Superspeciality Hospital Pvt. Ltd, Ahmedabad, India

7. Senior Consultant, Infectious Diseases and Tropical Medicine, Apollo Hospital, Chennai, India

8. Senior Consultant, Infectious Diseases, Apollo Hospitals International Ltd, Gandhinagar, India

9. Medical Affairs, Cadila Pharmaceuticals Ltd, Ahmedabad, India

Funder

Cadila Pharmaceuticals Ltd., Ahmedabad, India

Publisher

Informa UK Limited

Subject

Pharmacology,Immunology,Immunology and Allergy

Reference36 articles.

1. WHO Expert Consultation on Rabies prevention. Third report. Technical report series no. 1012. Geneva, Switzerland: World Health Organization; 2018.

2. World Health Organization. Rabies Vaccines and Immunoglobulins: WHO position, WHO/CDS/NTD/NZD/2018.04. Geneva, Switzerland: World Health Organization; 2018.

3. Minghui R, Stone M, Semedo MH, Nel L. New global strategic plan to eliminate dog-mediated rabies by 2030. Lancet Glob Health. 2018 Aug;6(8):e828–e829. doi: 10.1016/S2214-109X(18)30302-4. Epub 2018 Jun 18. PMID: 29929890.

4. World Health Organization. Rabies vaccines: WHO position paper – April 2018. Weekly Epidemiological Record, No. 16. 2018;93:201–20.

5. Vaccine Investment Strategy. Global alliance for vaccines and immunization. [accessed 2021 Mar 30] https://www.gavi.org/about/strategy/vaccine-investment-strategy.

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