Reappraisal of FDA approved drugs against Alzheimer’s disease based on differential gene expression and protein interaction network analysis: an in silico approach

Author:

G. N. S Hema Sree1,Ganesan Rajalekshmi Saraswathy12,Murahari Manikanta13ORCID,Burri Raghunadha R.4

Affiliation:

1. Pharmacological Modelling and Simulation Centre, M. S. Ramaiah University of Applied Sciences, Bangalore, Karnataka, India;

2. Department of Pharmacy Practice, Faculty of Pharmacy, M. S. Ramaiah University of Applied Sciences, Bangalore, Karnataka, India;

3. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, M. S. Ramaiah University of Applied Sciences, Bangalore, Karnataka, India;

4. Data Science, Dr. Reddy’s Laboratories, Hyderabad, India

Publisher

Informa UK Limited

Subject

Molecular Biology,General Medicine,Structural Biology

Reference59 articles.

1. Metal Ionophore Treatment Restores Dendritic Spine Density and Synaptic Protein Levels in a Mouse Model of Alzheimer's Disease

2. 2018 Alzheimer's disease facts and figures

3. Identifying natural compounds as multi-target-directed ligands against Alzheimer’s disease: an in silico approach

4. Potential involvement of GRIN2B encoding the NMDA receptor subunit NR2B in the spectrum of Alzheimer’s disease

5. Association, A. & Alzheimer’s Association. (2017). FDA-approved treatments for Alzheimer’s. Retrieved from https://www.alz.org/dementia/downloads/topicsheet_treatments.pdf%0Afile:///D:/002 current projects/003 NO APPROVAL/9999 review projects/ALZ REVIEW/AD new trial review 123@gmail.com/ALZHEIMER REVIEW.Data/PDF/3492138826/topicsheet_treatments.pdf

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