Molecular dynamics simulation of biased agonists at the dopamine D2 receptor suggests the mechanism of receptor functional selectivity
Author:
Affiliation:
1. College of Science and Mathematics, Rowan University, Glassboro, NJ, USA
Funder
National Science Foundation
Pittsburgh Supercomputing Center
Publisher
Informa UK Limited
Subject
Molecular Biology,General Medicine,Structural Biology
Link
https://www.tandfonline.com/doi/pdf/10.1080/07391102.2018.1513378
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1. Discovery of cariprazine (RGH-188): A novel antipsychotic acting on dopamine D3/D2 receptors
2. Discovery of -Arrestin-Biased Dopamine D2 Ligands for Probing Signal Transduction Pathways Essential for Antipsychotic Efficacy
3. Dopamine signaling in food addiction: role of dopamine D2 receptors
4. MILCH SHAKE: An efficient method for constraint dynamics applied to alkanes
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