Investigation of activation mechanism and conformational stability of N-(4-chloro-3-trifluoromethyl-phenyl)-2-ethoxybenzamide and N-(4-chloro-3-trifluoromethyl-phenyl)-2-ethoxy-6-pentadecyl-benzamide in the: active site of p300 histone acetyl transferase enzyme by molecular dynamics and binding free energy studies
Author:
Affiliation:
1. Laboratory of Biocrystallography and Computational Molecular Biology, Department of Physics, Periyar University, Salem, India
Publisher
Informa UK Limited
Subject
Molecular Biology,General Medicine,Structural Biology
Link
https://www.tandfonline.com/doi/pdf/10.1080/07391102.2018.1533497
Reference52 articles.
1. Regulation of chromatin by histone modifications
2. Histone acetylation and deacetylation: importance in inflammatory lung diseases
3. Cinnamoyl Compounds as Simple Molecules that Inhibit p300 Histone Acetyltransferase
4. The Identification of a Novel Natural Activator of p300 Histone Acetyltranferase Provides New Insights into the Modulation Mechanism of this Enzyme
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