How does the novel T315L mutation of breakpoint cluster region-abelson (BCR-ABL) kinase confer resistance to ponatinib: a comparative molecular dynamics simulation study

Author:

Zhang Hao1,He Xinheng1,Ni Duan1,Mou Linkai2,Chen Xiangyu3,Lu Shaoyong1

Affiliation:

1. Department of Pathophysiology Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University, School of Medicine, Shanghai, China;

2. Department of Urology, Affiliated Hospital of Weifang Medicinal University, Wei fang, Shandong, China;

3. Department of Medicinal Laboratory, Weifang Medicinal University, Weifang, Shandong, China

Funder

National Natural Science Foundation of China

Shanghai Health and Family Planning Commission

The Fundamental Research Funds for the Central Universities

Shandong Provincial Natural Science Foundation

Publisher

Informa UK Limited

Subject

Molecular Biology,General Medicine,Structural Biology

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