Combretum lanceolatum extract reverses anxiety and seizure behavior in adult zebrafish through GABAergic neurotransmission: an in vivo and in silico study

Author:

da Silva Antonio Wlisses12,Ferreira Maria Kueirislene A.2,Pereira Lucas Ramos3,Rebouças Emanuela L.14,Coutinho Marnielle Rodrigues4,Dos Joyce,Lima Reis2,Guedes Maria Izabel Florindo4,Bandeira Paulo N.5,Magalhães Francisco Ernani A.246,Menezes Jane Eire S. A. de2,Marinho Marcia Machado7,Teixeira Alexandre Magno Rodrigues15,Salles Trevisan Maria Teresa3ORCID,dos Santos Hélcio S.125,Marinho Emmanuel Silva8ORCID

Affiliation:

1. Northeast Biotechnology Network, Graduate Program of Biotechnology, State University of Ceará, Fortaleza, Ceará, Brazil

2. Itaperi Campus, Laboratory of Natural Products Chemistry - LQPN-S, State University of Ceará, Science and Technology Center (CCT), Fortaleza, Ceará, Brazil

3. Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, Ceará, Brazil

4. Itaperi Campus, Laboratory of Biotechnology and Molecular Biology, State University of Ceará, Health Sciences Center (CCS), Fortaleza, Ceará, Brazil

5. Postgraduate Program in Biological Chemistry, Department of Biological Chemistry, Regional University of Cariri, Crato, Ceará, Brazil

6. Department of Chemistry, Laboratory of Natural Products Bioprospecting and Biotechnology, CECITEC Campus, State University of Ceará, Tauá, Ceará, Brazil

7. Faculty of Education, Science and Letters of Iguatu, State University of Ceará, Iguatu, Ceara, Brazil

8. Faculty of Philosophy Dom Aureliano Matos, State University of Ceará, Limoeiro do Norte, Ceará, Brasil

Funder

CNPq

Hélcio Silva dos Santos acknowledges financial support from the PQ-BPI/FUNCAP

Publisher

Informa UK Limited

Subject

Molecular Biology,General Medicine,Structural Biology

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