Identification of novel peptide inhibitors for oncogenic KRAS G12D as therapeutic options using mutagenesis-based remodeling and MD simulations

Author:

Samad Abdus1,Khurshid Beenish1,Mahmood Arif2,Rehman Ashfaq Ur3,Khalid Asaad45,Abdalla Ashraf N.6,Algarni Alanood S.6,Wadood Abdul1

Affiliation:

1. Department of Biochemistry, Abdul Wali Khan University Mardan, Mardan, Pakistan

2. Center for Medical Genetics and Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China

3. Department of Molecular Biology and Biochemistry, School of Biological Sciences, University of California, Irvine, California, USA

4. Substance Abuse and Toxicology Research Center, Jazan University, Jazan, Saudi Arabia

5. Medicinal and Aromatic Plants and Traditional Medicine Research Institute, National Center for Research, Khartoum, Sudan

6. Department of Pharmacology and Toxicology, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia

Funder

Ministry of Education in Saudi Arabia

Publisher

Informa UK Limited

Subject

Molecular Biology,General Medicine,Structural Biology

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