Monomeric human soluble CD4 dimerizes at physiological temperature: VTSAXS data based modeling and screening of retardant molecules
Author:
Affiliation:
1. Protein Science and Engineering, CSIR-Institute of Microbial Technology, Chandigarh, India
2. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India
Funder
CSIR INDIA
Publisher
Informa UK Limited
Subject
Molecular Biology,General Medicine,Structural Biology
Link
https://www.tandfonline.com/doi/pdf/10.1080/07391102.2020.1771422
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1. Binding of Full-Length HIV-1 gp120 to CD4 Induces Structural Reorientation around the gp120 Core
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3. Bonsai Gelsolin Survives Heat Induced Denaturation by Forming β-Amyloids which Leach Out Functional Monomer
4. Visualizing Temperature Mediated Activation of Gelsolin and Its Deactivation By Pip2: A Saxs Based Study
5. Delineating CD4 dependency of HIV-1: Adaptation to infect low level CD4 expressing target cells widens cellular tropism but severely impacts on envelope functionality
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