Discovery and optimization of natural-based nanomolar c-Kit inhibitors via in silico and in vitro studies
Author:
Affiliation:
1. BK21 FOUR Team and Integrated Research Institute for Drug Development, College of Pharmacy, Dongguk University-Seoul, Goyang, Republic of Korea
2. Pharmaceutical Chemistry Department, Faculty of Pharmacy, Badr University in Cairo, Cairo, Egypt
Funder
National Research Foundation of Korea
the BK21 FOUR
Publisher
Informa UK Limited
Subject
Molecular Biology,General Medicine,Structural Biology
Link
https://www.tandfonline.com/doi/pdf/10.1080/07391102.2022.2164061
Reference59 articles.
1. Inhibition of c-Kit by tyrosine kinase inhibitors
2. Predicting protein flexibility through the prediction of local structures
3. In silico discovery of novel inhibitors from Northern African natural products database against main protease (Mpro) of SARS-CoV-2
4. Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases
5. A Missense Mutation in KIT Kinase Domain 1 Correlates with Imatinib Resistance in Gastrointestinal Stromal Tumors
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