Introducing of novel class of pyrano[2,3-<i>c</i>]pyrazole-5-carbonitrile analogs with potent antimicrobial activity, DNA gyrase inhibition, and prominent pharmacokinetic and CNS toxicity profiles supported by molecular dynamic simulation-Reference-Cited by-同舟云学术

Introducing of novel class of pyrano[2,3-c]pyrazole-5-carbonitrile analogs with potent antimicrobial activity, DNA gyrase inhibition, and prominent pharmacokinetic and CNS toxicity profiles supported by molecular dynamic simulation

Published:2023-09-03 Issue: Volume: Page:1-18
ISSN:0739-1102
Container-title:Journal of Biomolecular Structure and Dynamics
language:en
Short-container-title:Journal of Biomolecular Structure and Dynamics

Author:

Almaghrabi Mohammed¹,Musa Arafa²^ORCID,Aljohani Ahmed K. B.¹,Ahmed Hany E. A.³^ORCID,Alsulaimany Marwa¹,Miski Samar F.⁴,Mostafa Ehab M.²,Hussein Shaimaa⁵,Parambi Della Grace Thomas⁶,Ghoneim Mohammed M.⁷,Elgammal Walid E.⁸,Halawa Ahmed H.⁸,Hammad Ali³,El-Agrody Ahmed M.⁸

Affiliation:

1. Pharmacognosy and Pharmaceutical Chemistry Department, College of Pharmacy, Taibah University, Medina, Saudi Arabia

2. Department of Pharmacognosy, College of Pharmacy, Jouf University, Sakaka, Aljouf, Saudi Arabia

3. Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Nasr City, Cairo, Egypt

4. Pharmacology and Toxicology Department, College of Pharmacy, Taibah University, Medina, Saudi Arabia

5. Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Aljouf, Saudi Arabia

6. Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Aljouf, Saudi Arabia

7. Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Ad Diriyah, Saudi Arabia

8. Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Egypt

Funder

Deanship of Scientific Research at Jouf University

Publisher

Informa UK Limited

Subject

Molecular Biology,General Medicine,Structural Biology

Link

https://www.tandfonline.com/doi/pdf/10.1080/07391102.2023.2252088

Reference78 articles.

1. Design and Synthesis of 2-(4-Bromophenyl)Quinoline-4-Carbohydrazide Derivatives via Molecular Hybridization as Novel Microbial DNA-Gyrase Inhibitors

2. Antimicrobial and Antitumor Screening of Fluorescent 5,7-Dihydroxy-4-Propyl-2H-Chromen-2-One Derivatives with Docking Studies

3. Design, Synthesis, and Docking Studies of 4H-Chromene and Chromene Based Azo Chromophores: A Novel Series of Potent Antimicrobial and Anticancer Agents

4. Design, synthesis, molecular docking of new lipophilic acetamide derivatives affording potential anticancer and antimicrobial agents

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