Design, synthesis, biological evaluation and docking analysis of pyrrolidine-benzenesulfonamides as carbonic anhydrase or acetylcholinesterase inhibitors and antimicrobial agents

Author:

Poyraz Samet1ORCID,Döndaş H. Ali12ORCID,Yamali Cem1,Belveren Samet1,Demir Yeliz3ORCID,Aydınoglu Sabriye4,Döndaş Naciye Yaktubay5ORCID,Taskin-Tok Tugba67ORCID,Taş Senanur2,Ülger Mahmut8,Sansano Jose M.9ORCID

Affiliation:

1. Department of Basic Pharmaceutical Sciences, Faculty of Pharmacy, Çukurova University, Balcalı, Adana, Türkiye

2. Department of Biotechnology, Institute of Natural and Applied Sciences, Çukurova University, Balcalı, Adana, Türkiye

3. Department of Pharmacy Services, Nihat Delibalta Göle Vocational High School, Ardahan University, Ardahan, Türkiye

4. Department of Analytical Chemistry, Faculty of Pharmacy, Çukurova University, Balcalı, Adana, Türkiye

5. Department of Pharmacology, Faculty of Medicine, Çukurova University, Balcalı, Adana, Türkiye

6. Department of Chemistry, Faculty of Arts and Sciences, Gaziantep University, Gaziantep, Türkiye

7. gDepartment of Bioinformatics and Computational Biology, Institute of Health Sciences, Gaziantep University, Gaziantep, Türkiye

8. Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Mersin University, Mersin, Türkiye

9. Department of Organic Chemistry, Centro de Innovación en Química Avanzada (ORFEO-CINQA), University of Alicante, and Instituto de Síntesis Orgánica (ISO), Alicante, Spain

Funder

ukurova University

Publisher

Informa UK Limited

Subject

Molecular Biology,General Medicine,Structural Biology

Reference85 articles.

1. Acalabrutinib: A Selective Bruton Tyrosine Kinase Inhibitor for the Treatment of B-Cell Malignancies

2. Accelrys Software Inc. (2013). Discovery studio modeling environment . Release 3.5 Accelrys Software Inc San Diego

3. Amani Shafeek Awaad AMAA Reham Mostafa & El-Meligy (2017). Amino substituted acetamide derivative. US 9 598 361 BI. King Saud University;

4. A review on cholinesterase inhibitors for Alzheimer’s disease

5. Polypharmacology of epacadostat: a potent and selective inhibitor of the tumor associated carbonic anhydrases IX and XII

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