Identification of selective inhibitors for phosphodiesterase 5A using e-pharmacophore modelling and large-scale virtual screening-based structure guided drug discovery approaches-Reference-Cited by-同舟云学术

Identification of selective inhibitors for phosphodiesterase 5A using e-pharmacophore modelling and large-scale virtual screening-based structure guided drug discovery approaches

Published:2023-08-06 Issue: Volume: Page:1-16
ISSN:0739-1102
Container-title:Journal of Biomolecular Structure and Dynamics
language:en
Short-container-title:Journal of Biomolecular Structure and Dynamics

Author:

Maryam Arooma¹²³⁴,Siddiqi Abdul Rauf¹,Chaitanya Vedithi Sundeep³,Ece Abdulilah⁴^ORCID,Khalid Rana Rehan⁵^ORCID

Affiliation:

1. Department of Biosciences, COMSATS University Islamabad (CUI), Islamabad, Pakistan

2. Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA, USA

3. Department of Biochemistry, University of Cambridge, Cambridge, UK

4. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Biruni University, Istanbul, Turkey

5. National Center for Bioinformatics, Quaid-i-Azam University, Islamabad, Pakistan

Publisher

Informa UK Limited

Subject

Molecular Biology,General Medicine,Structural Biology

Link

https://www.tandfonline.com/doi/pdf/10.1080/07391102.2023.2242491

Reference54 articles.

1. Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules

2. PLIP 2021: expanding the scope of the protein–ligand interaction profiler to DNA and RNA

3. Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the γ-subunit

4. RETRACTED ARTICLE: cGMP-phosphodiesterase 6, transducin and Wnt5a/Frizzled-2-signaling control cGMP and Ca2+ homeostasis in melanoma cells

5. Assessing the Performance of 3D Pharmacophore Models in Virtual Screening: How Good are They?

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