<i>In silico</i> approach reveals <i>N</i> -(5-phenoxythiophen-2-yl)-2-(arylthio)acetamides as promising selective SIRT2 inhibitors: the case of structural optimization of virtual screening-derived hits-Reference-Cited by-同舟云学术

In silico approach reveals N -(5-phenoxythiophen-2-yl)-2-(arylthio)acetamides as promising selective SIRT2 inhibitors: the case of structural optimization of virtual screening-derived hits

Published:2023-12-19 Issue: Volume: Page:1-12
ISSN:0739-1102
Container-title:Journal of Biomolecular Structure and Dynamics
language:en
Short-container-title:Journal of Biomolecular Structure and Dynamics

Author:

Gozelle Mahmut¹,Bakar-Ates Filiz²,Massarotti Alberto³,Ozkan Erva⁴,Gunindi Habibe Beyza¹,Ozkan Yesim⁵,Eren Gokcen¹

Affiliation:

1. SIRTeam Group, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Ankara, Türkiye

2. Department of Biochemistry, Faculty of Pharmacy, Ankara University, Ankara, Türkiye

3. Dipartimento di Scienze del Farmaco, Università degli Studi del Piemonte Orientale, “A. Avogadro”, Novara, Italy

4. Department of Biochemistry, Faculty of Pharmacy, Ankara Medipol University, Ankara, Türkiye

5. Department of Biochemistry, Faculty of Pharmacy, Gazi University, Ankara, Türkiye

Funder

Scientific and Technological Research Council of Turkey

Publisher

Informa UK Limited

Subject

Molecular Biology,General Medicine,Structural Biology

Link

https://www.tandfonline.com/doi/pdf/10.1080/07391102.2023.2293252

Reference55 articles.

1. Virtual Screening in the Identification of Sirtuins’ Activity Modulators

2. 5-((3-Amidobenzyl)oxy)nicotinamides as Sirtuin 2 Inhibitors

3. N-(5-substituted) thiophene-2-alkylsulfonamides as potent inhibitors of 5-lipoxygenase

4. The chemical biology of sirtuins

5. The role of SIRT2 in cancer: A novel therapeutic target

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