Molecular dynamic mechanism(s) of inhibition of bioactive antiviral phytochemical compounds targeting cytochrome P450 3A4 and P-glycoprotein-Reference-Cited by-同舟云学术

Molecular dynamic mechanism(s) of inhibition of bioactive antiviral phytochemical compounds targeting cytochrome P450 3A4 and P-glycoprotein

Published:2020-10-16 Issue:3 Volume:40 Page:1037-1047
ISSN:0739-1102
Container-title:Journal of Biomolecular Structure and Dynamics
language:en
Short-container-title:Journal of Biomolecular Structure and Dynamics

Author:

Kehinde Idowu¹,Ramharack Pritika²,Nlooto Manimbulu²³,Gordon Michelle¹

Affiliation:

1. KwaZulu-Natal Research, Innovation and Sequencing Platform (KRISP)/Genomics Unit, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa

2. Discipline of Pharmacy, School of Health Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa

3. Department of Pharmaceutical Sciences, Healthcare Sciences, University of Limpopo, Durban, South Africa

Publisher

Informa UK Limited

Subject

Molecular Biology,General Medicine,Structural Biology

Link

https://www.tandfonline.com/doi/pdf/10.1080/07391102.2020.1821780

Reference56 articles.

1. Enhanced Oral Bioavailability of Diltiazem by the Influence of Gallic Acid and Ellagic Acid in Male Wistar Rats: Involvement of CYP3A and P-gp Inhibition

2. Effects of Temperature Control Algorithms on Transport Properties and Kinetics in Molecular Dynamics Simulations

3. Protease inhibitors atazanavir, lopinavir and ritonavir are potent blockers, but poor substrates, of ABC transporters in a broad panel of ABC transporter-overexpressing cell lines