Identification of destabilizing SNPs in SARS-CoV2-ACE2 protein and spike glycoprotein: implications for virus entry mechanisms
Author:
Affiliation:
1. Computational Biology Research Lab, Department of Computer Science, National University of Computing and Emerging Sciences, NUCES-FAST, Islamabad, Pakistan
Publisher
Informa UK Limited
Subject
Molecular Biology,General Medicine,Structural Biology
Link
https://www.tandfonline.com/doi/pdf/10.1080/07391102.2020.1823885
Reference39 articles.
1. UniProt: the Universal Protein knowledgebase
2. SARS-CoV-2, an evolutionary perspective of interaction with human ACE2 reveals undiscovered amino acids necessary for complex stability
3. nsSNPAnalyzer: identifying disease-associated nonsynonymous single nucleotide polymorphisms
4. Calcium ion binding to calmodulin: binding free energy calculation using the molecular mechanics Poisson-Boltzmann surface area (MM-PBSA) method by incorporating implicit polarization
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