In vitro–in vivo extrapolation of metabolic clearance using human liver microsomes: factors showing variability and their normalization
Author:
Affiliation:
1. Research Institute of Pharmaceutical Sciences, Musashino University, Tokyo, Japan;
2. Translational Research Division, Chugai Pharmaceutical, Co., Ltd, Kanagawa, Japan;
3. Research Division, Chugai Pharmaceutical, Co., Ltd, Shizuoka, Japan
Publisher
Informa UK Limited
Subject
Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine
Link
https://www.tandfonline.com/doi/pdf/10.1080/00498254.2020.1738592
Reference94 articles.
1. The Influence of Nonspecific Microsomal Binding on Apparent Intrinsic Clearance, and Its Prediction from Physicochemical Properties
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4. Scaling Factors for the Extrapolation of In Vivo Metabolic Drug Clearance From In Vitro Data: Reaching a Consensus on Values of Human Micro-somal Protein and Hepatocellularity Per Gram of Liver
5. Covariation of Human Microsomal Protein Per Gram of Liver with Age: Absence of Influence of Operator and Sample Storage May Justify Interlaboratory Data Pooling
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