Translational PK/PD framework for antibody-drug conjugates to inform drug discovery and development
Author:
Affiliation:
1. Genentech Inc., South San Francisco, CA, 94080
2. Zymeworks, Vancouver BC, Canada V5T 1G4
Publisher
Informa UK Limited
Link
https://www.tandfonline.com/doi/pdf/10.1080/00498254.2024.2351044
Reference38 articles.
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2. Ait-Oudhia S Zhang W Mager DE. (2017). A Mechanism-Based PK/PD Model for Hematological Toxicities Induced by Antibody-Drug Conjugates. Aaps j 19 1436-48.
3. Bender BC Schaedeli-Stark F Koch R Joshi A Chu YW Rugo H Krop IE Girish S Friberg LE Gupta M. (2012). A population pharmacokinetic/pharmacodynamic model of thrombocytopenia characterizing the effect of trastuzumab emtansine (T-DM1) on platelet counts in patients with HER2-positive metastatic breast cancer. Cancer chemotherapy and pharmacology 70 591-601.
4. Betts A Clark T Jasper P Tolsma J van der Graaf PH Graziani EI Rosfjord E Sung M Ma D Barletta F. (2020). Use of translational modeling and simulation for quantitative comparison of PF-06804103 a new generation HER2 ADC with Trastuzumab-DM1. Journal of pharmacokinetics and pharmacodynamics 47 513-26.
5. Betts AM Haddish-Berhane N Tolsma J Jasper P King LE Sun Y Chakrapani S Shor B Boni J Johnson TR. (2016). Preclinical to Clinical Translation of Antibody-Drug Conjugates Using PK/PD Modeling: a Retrospective Analysis of Inotuzumab Ozogamicin. The AAPS Journal 18 1101-16.
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1. Preface for Special Issue: “Emerging strategies, technologies and approaches for the next generation ADCs”;Xenobiotica;2024-07-29
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