Development of a physiologically based pharmacokinetic model for levetiracetam in patients with renal impairment to guide dose adjustment based on steady-state peak/trough concentrations
Author:
Affiliation:
1. Department of Pharmacy, Medical Security Center, Chinese PLA General Hospital, Beijing, People’s Republic of China
2. Chinese PAP qinghai Hospital, Xining, People’s Republic of China
Funder
National Key Research and Development Program of China under Grant
Publisher
Informa UK Limited
Link
https://www.tandfonline.com/doi/pdf/10.1080/00498254.2024.2317888
Reference29 articles.
1. Incidence of Acute Renal Failure in Patients Using Levetiracetam Versus Other Antiseizure Medications: A Voluntary Post-Authorization Safety Study
2. Multifocal myoclonus as a presentation of levetiracetam toxicity
3. Pharmacokinetics of levetiracetam in patients with moderate to severe liver cirrhosis (Child-Pugh classes A, B, and C): Characterization by dynamic liver function tests
4. Levetiracetam dosing in patients receiving continuous renal replacement therapy
5. Dose optimization in kidney disease: opportunities for PBPK modeling and simulation;Franchetti Y;J Clin Pharmacol,2020
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