Methyl-hydroxylation and subsequent oxidation to produce carboxylic acid is the major metabolic pathway of tolbutamide in chimeric TK-NOG mice transplanted with human hepatocytes-Reference-Cited by-同舟云学术

Methyl-hydroxylation and subsequent oxidation to produce carboxylic acid is the major metabolic pathway of tolbutamide in chimeric TK-NOG mice transplanted with human hepatocytes

Published:2021-02-18 Issue:5 Volume:51 Page:582-589
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Uehara Shotaro¹^ORCID,Yoneda Nao¹,Higuchi Yuichiro¹,Yamazaki Hiroshi²^ORCID,Suemizu Hiroshi¹^ORCID

Affiliation:

1. Central Institute for Experimental Animals, Kawasaki, Japan

2. Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/00498254.2021.1875515

Reference37 articles.

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5. Cytochromes P450: A Structure-Based Summary of Biotransformations Using Representative Substrates

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