Human mass balance, pharmacokinetics and metabolism of rovatirelin and identification of its metabolic enzymes in vitro-Reference-Cited by-同舟云学术

Human mass balance, pharmacokinetics and metabolism of rovatirelin and identification of its metabolic enzymes in vitro

Published:2019-03-05 Issue:12 Volume:49 Page:1434-1446
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Kobayshi Kaoru¹,Abe Yoshikazu¹,Kawai Asuka²,Furihata Takao²,Harada Hiroshi¹,Endo Takuro¹,Takeda Hiroo¹

Affiliation:

1. Central Research Laboratories, Kissei Pharmaceutical Co., Ltd, Azumino, Nagano, Japan;

2. Department of Clinical Projects Management, Kissei Pharmaceutical Co., Ltd, Bunkyo, Tokyo, Japan

Funder

Kissei Pharmaceutical Co., Ltd

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/00498254.2019.1580796

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5. Peptidase Inactivation of Hypothalamic Releasing Hormones

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3. Pharmacokinetic Drug Interactions of an Orally Available TRH Analog (Rovatirelin) With a CYP3A4/5 and P‐Glycoprotein Inhibitor (Itraconazole);The Journal of Clinical Pharmacology;2020-05-27

4. The Thyrotropin-Releasing Hormone-Degrading Ectoenzyme, a Therapeutic Target?;Frontiers in Pharmacology;2020-05-08

5. Synthesis and evaluation of in vivo anti‐hypothermic effect of all stereoisomers of the thyrotropin‐releasing hormone mimetic: Rovatirelin Hydrate;Journal of Peptide Science;2019-11-12