Plasma and hepatic concentrations of acetaminophen and its primary conjugates after oral administrations determined in experimental animals and humans and extrapolated by pharmacokinetic modeling-Reference-Cited by-同舟云学术

Plasma and hepatic concentrations of acetaminophen and its primary conjugates after oral administrations determined in experimental animals and humans and extrapolated by pharmacokinetic modeling

Published:2020-11-19 Issue:3 Volume:51 Page:316-323
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Toda Akiko¹,Shimizu Makiko²,Uehara Shotaro²³^ORCID,Sasaki Tatsuro²,Miura Tomonori²,Mogi Masayuki¹⁴,Utoh Masahiro¹²⁵,Suemizu Hiroshi³^ORCID,Yamazaki Hiroshi²^ORCID

Affiliation:

1. Pharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories, Ltd., Wakayama, Japan;

2. Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Tokyo, Japan;

3. Laboratory Animal Research Department, Central Institute for Experimental Animals, Kawasaki, Japan;

4. Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd., Kagoshima, Japan;

5. Scientific Affairs Division, Shin Nippon Biomedical Laboratories, Ltd., Tokyo, Japan

Funder

METI Artificial Intelligence-based Substance Hazard Integrated Prediction System Project

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research

Young Scientists

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/00498254.2020.1849872

Reference28 articles.

1. Acetaminophen cytotoxicity in HepG2 cells is associated with a decoupling of glycolysis from the TCA cycle, loss of NADPH production, and suppression of anabolism

2. Paracetamol (Acetaminophen)-Induced Toxicity: Molecular and Biochemical Mechanisms, Analogues and Protective Approaches

3. Marmosets are stars of Japan’s ambitious brain project

4. Metabolism and Effects on Endogenous Metabolism of Paracetamol (Acetaminophen) in a Porcine Model of Liver Failure

5. The reconstituted ‘humanized liver’ in TK-NOG mice is mature and functional

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