Metabolism and disposition in rats, dogs, and humans of erdafitinib, an orally administered potent pan-fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor-Reference-Cited by-同舟云学术

Metabolism and disposition in rats, dogs, and humans of erdafitinib, an orally administered potent pan-fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor

Published:2020-09-20 Issue:2 Volume:51 Page:177-193
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Scheers Ellen¹,Borgmans Carine¹,Keung Chi²,Bohets Hilde³,Wynant Inneke¹,Poggesi Italo⁴,Cuyckens Filip¹,Leclercq Laurent¹,Mamidi Rao N. V. S.⁵

Affiliation:

1. Drug Metabolism & Pharmacokinetics, Janssen Research & Development, Beerse, Belgium

2. Clinical Pharmacology, Janssen Research & Development, LLC, Raritan, NJ, USA

3. Preclinical Development, Janssen Research & Development, Beerse, Belgium

4. Clinical Pharmacology, Jan-Cil Italy, Cologno Monzese, Italy

5. Preclinical Development & Safety, Janssen Research & Development, LLC, Raritan, NJ, USA

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/00498254.2020.1821123

Reference19 articles.

1. BALVERSATM (erdafitinib). (2019) Prescribing Information. Janssen Products, LP, Horsham, PA. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/212018s000lbl.pdf. Accessed on April 15, 2020.

2. Clinical Pharmacogenetics Implementation Consortium Guidelines for Cytochrome P450 2D6 Genotype and Codeine Therapy: 2014 Update

3. Improved liquid chromatography—Online radioactivity detection for metabolite profiling

4. Fibroblast Growth Factor Receptor Inhibitors as a Cancer Treatment: From a Biologic Rationale to Medical Perspectives

5. European Medicines Agency (EMA). (2012). Guideline on Bioanalytical Method Validation. Available from: https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-bioanalytical-method-validation_en.pdf. Accessed on August 28, 2020.

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