ADME and DMPK considerations for the discovery and development of antibody drug conjugates (ADCs)-Reference-Cited by-同舟云学术

ADME and DMPK considerations for the discovery and development of antibody drug conjugates (ADCs)

Published:2022-08-03 Issue:8 Volume:52 Page:770-785
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Beaumont Kevin¹,Pike Andy¹,Davies Michael¹,Savoca Adriana¹,Vasalou Christina²,Harlfinger Steffi¹,Ramsden Diane²,Ferguson Douglas²,Hariparsad Niresh²,Jones Owen¹,McGinnity Dermot¹

Affiliation:

1. Drug Metabolism and Pharmacokinetics, Early Oncology Research and Development, Cambridge, UK

2. Drug Metabolism and Pharmacokinetics, Early Oncology Research and Development, AstraZeneca, Boston, MA, USA

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/00498254.2022.2141667

Reference92 articles.

1. A Mechanistic Pharmacokinetic Model Elucidating the Disposition of Trastuzumab Emtansine (T-DM1), an Antibody–Drug Conjugate (ADC) for Treatment of Metastatic Breast Cancer

2. Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates

3. Use of translational modeling and simulation for quantitative comparison of PF-06804103, a new generation HER2 ADC, with Trastuzumab-DM1

4. Current possibilities of liquid chromatography for the characterization of antibody-drug conjugates

5. Sacituzumab Govitecan (IMMU-132), an Anti-Trop-2/SN-38 Antibody–Drug Conjugate: Characterization and Efficacy in Pancreatic, Gastric, and Other Cancers

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3. Towards a platform quantitative systems pharmacology (QSP) model for preclinical to clinical translation of antibody drug conjugates (ADCs);Journal of Pharmacokinetics and Pharmacodynamics;2023-10-03

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