Drug clearance by aldehyde oxidase: can we avoid clinical failure?
Author:
Affiliation:
1. Development Science, UCB Biopharma, Braine-l’Alleud, Belgium
2. Development Science, UCB Biopharma, Slough, UK
Publisher
Informa UK Limited
Subject
Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine
Link
https://www.tandfonline.com/doi/pdf/10.1080/00498254.2022.2129519
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2. Site-Directed Mutagenesis at the Molybdenum Pterin Cofactor Site of the Human Aldehyde Oxidase: Interrogating the Kinetic Differences Between Human and Cynomolgus Monkey
3. Role of Molybdenum-Containing Enzymes in the Biotransformation of the Novel Ghrelin Receptor Inverse Agonist PF-5190457: A Reverse Translational Bed-to-Bench Approach
4. Purification and Mechanism of Human Aldehyde Oxidase Expressed inEscherichia coli
5. N-Acetyltransferase 2 Genotype-Dependent N-Acetylation of Hydralazine in Human Hepatocytes
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1. Evaluation of Icotinib as a Potent and Selective Inhibitor of Aldehyde Oxidase for Reaction Phenotyping in Human Hepatocytes;Drug Metabolism and Disposition;2024-04-02
2. Challenges and Opportunities for In Vitro–In Vivo Extrapolation of Aldehyde Oxidase-Mediated Clearance: Toward a Roadmap for Quantitative Translation;Drug Metabolism and Disposition;2023-09-26
3. Drug Design and Success of Prospective Mouse In Vitro–In Vivo Extrapolation (IVIVE) for Predictions of Plasma Clearance (CLp) from Hepatocyte Intrinsic Clearance (CLint);Molecular Pharmaceutics;2023-05-26
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