Investigation of disposition for TAK-448, a synthetic peptide of kisspeptin analog, in rats and dogs using the radiolabeled TAK-448 suitable for pharmacokinetic study
Author:
Affiliation:
1. Drug Metabolism and Pharmacokinetics Research Laboratories, Research, Takeda Pharmaceutical Company Limited, Kanagawa, Japan;
2. Analytical Development, Pharmaceutical Sciences, Takeda Pharmaceutical Company Limited, Osaka, Japan
Publisher
Informa UK Limited
Subject
Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine
Link
https://www.tandfonline.com/doi/pdf/10.1080/00498254.2018.1499152
Reference15 articles.
1. Endothelial Cell-to-Cell Junctions: Molecular Organization and Role in Vascular Homeostasis
2. Comparison of the metabolism of uniformly 14C-labelled l-phenylalanine, l-tyrosine and l-tryptophan in the rat
3. Gonadotropin-Releasing Hormone Neurons Extend Complex Highly Branched Dendritic Trees Outside the Blood-Brain Barrier
4. Disposition of DN-2327, a New Anxiolytic, in Rats, Dogs, and Monkeys.
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3. The Enhancement of Subcutaneous First-Pass Metabolism Causes Nonlinear Pharmacokinetics of TAK-448 after a Single Subcutaneous Administration to Rats;Drug Metabolism and Disposition;2019-06-14
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