Evaluation of interconversion pharmacokinetics of 16α-hydroxycleroda-3,13(14)Z-dien-15,16-olide – a novel HMG-CoA reductase inhibitor and its acid metabolite using multi-compartmental pharmacokinetic model in mice-Reference-Cited by-同舟云学术

Evaluation of interconversion pharmacokinetics of 16α-hydroxycleroda-3,13(14)Z-dien-15,16-olide – a novel HMG-CoA reductase inhibitor and its acid metabolite using multi-compartmental pharmacokinetic model in mice

Published:2018-04-11 Issue:4 Volume:49 Page:474-483
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Laxman Tulsankar Sachin¹²,Puttervu Santosh Kumar¹²,Mishra Anjali¹,Verma Sarvesh¹,Singh S. P.³,Sashidhara K. V.³,Marandi C. M.⁴,Saxena Shivani⁴,Yadav Manoj K.³,Bhatta Rabi S.¹⁴

Affiliation:

1. Pharmacokinetics & Metabolism Division, CSIR-Central Drug Research Institute, Lucknow, India;

2. Academy of Scientific and Innovative Research (AcSIR), New Delhi, India;

3. Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow, India;

4. Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Rae Bareli, India

Funder

Council of Scientific & Industrial Research

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/00498254.2018.1451933

Reference13 articles.

1. Simultaneous estimation of 16α-hydroxycleroda-3,13(14) Z-dien-15,16-olide from Polyalthia longifolia and its metabolite in hamster plasma: application to pharmacokinetic study

2. Concepts, properties, measurement, and computation of clearance rates of hormones and other substances in biological systems

3. The determination of essential clearance, volume, and residence time parameters of recirculating metabolic systems: The reversible metabolism of methylprednisolone and methylprednisone in rabbits

4. FDA U. 2013. Draft guidance for industry: bioanalytical method validation. US Department of Health and Human Services, US FDA.