Comparison of the inhibitory effect of ketoconazole, voriconazole, fluconazole, and itraconazole on the pharmacokinetics of bosentan and its corresponding active metabolite hydroxy bosentan in rats-Reference-Cited by-同舟云学术

Comparison of the inhibitory effect of ketoconazole, voriconazole, fluconazole, and itraconazole on the pharmacokinetics of bosentan and its corresponding active metabolite hydroxy bosentan in rats

Published:2019-07-03 Issue:3 Volume:50 Page:280-287
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Chen Mengchun¹,Zhang Xufei²,Chen Yijie³^ORCID,Sun Wei¹,Wang Zhe¹,Huang Chengke¹,Hu Guoxin⁴,Chen Ruijie¹

Affiliation:

1. Department of Pharmacy, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China;

2. Laboratory of Animal Centre, Wenzhou Medical University, Wenzhou, China;

3. Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China;

4. School of Pharmacy, Wenzhou Medical University, Wenzhou, China

Funder

Zhejiang Natural Science Foundation

Wenzhou Science and Technology Plan Project

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/00498254.2019.1628321

Reference37 articles.

1. Pharmacokinetics, safety, and efficacy of bosentan in pediatric patients with pulmonary arterial hypertension

2. Pharmacokinetics and Tissue Penetration of Fluconazole in Humans

3. Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebocontrolled study

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