Relevance of preclinical rodent pharmacokinetics in the selection of a companion antibiotic for combining with beta-lactamase inhibitor
Author:
Affiliation:
1. Department of Drug Metabolism and Pharmacokinetics, Zydus Research Centre, Ahmadabad, India;
2. Department of Pharmacology and Toxicology, Zydus Research Centre, Ahmadabad, India
Publisher
Informa UK Limited
Subject
Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine
Link
https://www.tandfonline.com/doi/pdf/10.1080/00498254.2019.1696494
Reference13 articles.
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2. The Novel β-Lactam Enhancer Zidebactam Augments theIn VivoPharmacodynamic Activity of Cefepime in a Neutropenic Mouse LungAcinetobacter baumanniiInfection Model
3. Bhatia A, Gupta M, Chugh R, Friedland HD. (2016). Zidebactam phase 1 single ascending dose and crossover study in healthy subjects. Poster 2236. Poster Presented at ID Week; 2016 Oct 26–30; New Orleans, LA, USA.
4. Game Changers: New β-Lactamase Inhibitor Combinations Targeting Antibiotic Resistance in Gram-Negative Bacteria
5. Key Pharmacokinetic Essentials of Fixed-Dosed Combination Products: Case Studies and Perspectives
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