A novel Css-MRTpo approach to simulate oral plasma concentration–time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite in humans using chimeric mice with humanized livers-Reference-Cited by-同舟云学术

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A novel Css-MRTpo approach to simulate oral plasma concentration–time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite in humans using chimeric mice with humanized livers

Published:2019-11-22 Issue:7 Volume:50 Page:761-768
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Kamimura Hidetaka¹^ORCID,Uehara Shotaro¹^ORCID,Suemizu Hiroshi¹^ORCID

Affiliation:

1. Laboratory Animal Research Department, Central Institute for Experimental Animals, Kawasaki, Japan

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/00498254.2019.1693082

Reference38 articles.

1. A Perspective on the Prediction of Drug Pharmacokinetics and Disposition in Drug Research and Development

2. Prediction of human oral pharmacokinetics using nonclinical data: examples involving four proprietary compounds

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Empirical scaling factor for predicting human pharmacokinetic profiles of disproportionate metabolites using the Css–MRTpo method and chimeric mice with humanised livers;Xenobiotica;2023-09-02

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