In vivo-in vitro correlation of antitumor activity of heat shock protein 90 (HSP90) inhibitors with a pharmacokinetics/pharmacodynamics analysis using NCI-N87 xenograft mice-Reference-Cited by-同舟云学术

In vivo-in vitro correlation of antitumor activity of heat shock protein 90 (HSP90) inhibitors with a pharmacokinetics/pharmacodynamics analysis using NCI-N87 xenograft mice

Published:2021-08-19 Issue:9 Volume:51 Page:968-976
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Ohminato Noriaki¹²,Nagayasu Miho³,Ozeki Kazuhisa⁴,Saitoh Ryoichi⁵,Ono Naomi⁵,Shibahara Norihito⁴,Suda Atsushi⁶,Yoshinari Kouichi²

Affiliation:

1. Chugai Research Institute for Medical Science, Inc., Gotemba, Shizuoka, Japan

2. Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan

3. Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan

4. Translational Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan

5. Research Division, Chugai Pharmaceutical Co., Ltd., Fujisawa, Kanagawa, Japan; f Sustainability Department, Chugai Pharmaceutical Co., Ltd., Chuo-ku, Tokyo, Japan

6. Sustainability Department, Chugai Pharmaceutical Co., Ltd., Chuo-ku, Tokyo, Japan

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/00498254.2021.1942588

Reference35 articles.

1. Translational Pharmacology: Harnessing Increased Specialization of Research Within the Basic Biological Sciences

2. Heat Shock Protein 90 as a Drug Target: Some Like It Hot

3. Pharmacokinetics/pharmacodynamics and the stages of drug development: Role of modeling and simulation

4. Preclinical assessment of novel BRAF inhibitors: integrating pharmacokinetic-pharmacodynamic modelling in the drug discovery process