Pharmacokinetics, metabolism and off-target effects in the rat of 8-[(1H- benzotriazol-1-yl)amino]octanoic acid, a selective inhibitor of human cytochrome P450 4Z1: β-oxidation as a potential augmenting pathway for inhibition-Reference-Cited by-同舟云学术

Pharmacokinetics, metabolism and off-target effects in the rat of 8-[(1H- benzotriazol-1-yl)amino]octanoic acid, a selective inhibitor of human cytochrome P450 4Z1: β-oxidation as a potential augmenting pathway for inhibition

Published:2021-06-11 Issue:8 Volume:51 Page:901-915
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Kowalski John P.¹²^ORCID,Pelletier Robert D.¹,McDonald Matthew G.¹²,Kelly Edward J.³,Rettie Allan E.¹

Affiliation:

1. Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, WA, USA

2. Department of Drug Metabolism and Pharmacokinetics, Pfizer Boulder R&D, Boulder, CO, USA

3. Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA, USA

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/00498254.2021.1930281

Reference39 articles.

1. Periodontitis as an Independent Factor in Pathogenesis of Erectile Dysfunction

2. The Metabolism, Analysis, and Targeting of Steroid Hormones in Breast and Prostate Cancer

3. Cytochrome P450 probe substrate metabolism kinetics in Sprague Dawley rats

4. Metabolism of Xenobiotic Carboxylic Acids: Focus on Coenzyme A Conjugation, Reactivity, and Interference with Lipid Metabolism

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