Preclinical metabolism and disposition of an orally bioavailable macrocyclic FXIa inhibitor-Reference-Cited by-同舟云学术

Preclinical metabolism and disposition of an orally bioavailable macrocyclic FXIa inhibitor

Published:2021-07-05 Issue:8 Volume:51 Page:933-948
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Chacko Silvi A.¹,Yang Wu²,Wang Yufeng²,Tian Yuan²,Hong Yang²,Wallace Michael²,Wang Bonnie¹,Ewing William R.²,Luettgen Joseph M.³,Shu Yue-Zhong¹,Christopher Lisa J.¹

Affiliation:

1. Department of Nonclinical Research and Development, Bristol Myers Squibb Pharmaceutical Research and Development, Princeton, NJ, USA

2. Discovery Chemistry, Bristol Myers Squibb Pharmaceutical Research and Development, Princeton, NJ, USA

3. Discovery Biology, Bristol Myers Squibb Pharmaceutical Research and Development, Princeton, NJ, USA

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/00498254.2021.1943565

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4. Delineating Novel Metabolic Pathways of DPC 963, a Non-Nucleoside Reverse Transcriptase Inhibitor, in Rats. Characterization of Glutathione Conjugates of Postulated Oxirene and Benzoquinone Imine Intermediates by LC/MS and LC/NMR

5. The effect of varying halogen substituent patterns on the cytochrome P450 catalysed dehalogenation of 4-halogenated anilines to 4-aminophenol metabolites

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