The in vivo disposition of subcutaneous injected 14C-razuprotafib (14C-AKB-9778), a sulphamic acid phosphatase inhibitor, in nonclinical species and human-Reference-Cited by-同舟云学术

The in vivo disposition of subcutaneous injected 14C-razuprotafib (14C-AKB-9778), a sulphamic acid phosphatase inhibitor, in nonclinical species and human

Published:2021-09-01 Issue:10 Volume:51 Page:1132-1145
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Soldo Brandi Lynn¹^ORCID,Camilleri Patrick²,Buch Akshay¹,Janusz John¹

Affiliation:

1. Aerpio Pharmaceuticals, Cincinnati, OH, USA

2. Bio-Chemical Solutions, Stevenage, UK

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/00498254.2021.1972358

Reference20 articles.

1. Camilleri P, Soldo B, Buch A, Janusz J. 2021. Oxidative metabolism of razuprotafib, a sulfamic acid phosp hatase inhibitor, in human microsomes and recombinant human CYP2C8 enzyme. Xenobiotica:1–12. DOI:10.1080/00498254.2021.1969482

2. Targeting Tie2 for Treatment of Diabetic Retinopathy and Diabetic Macular Edema

3. Treatment of Diabetic Macular Edema with an Inhibitor of Vascular Endothelial-Protein Tyrosine Phosphatase That Activates Tie2

4. Metabolism of Cyclamate and Its Conversion to Cyclohexylamine

5. The Pharmacokinetics of Fondaparinux Sodium in Healthy Volunteers

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1. Monooxygenase- and Dioxygenase-Catalyzed Oxidative Dearomatization of Thiophenes by Sulfoxidation, cis-Dihydroxylation and Epoxidation;International Journal of Molecular Sciences;2022-01-14

2. Oxidative metabolism of razuprotafib (AKB-9778), a sulfamic acid phosphatase inhibitor, in human microsomes and recombinant human CYP2C8 enzyme;Xenobiotica;2021-09-03