Disposition and metabolism of [14C]-galunisertib, a TGF-βRI kinase/ALK5 inhibitor, following oral administration in healthy subjects and mechanistic prediction of the effect of itraconazole on galunisertib pharmacokinetics
Author:
Affiliation:
1. Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA and
2. Eli Lilly and Company Erl Wood, Windlesham, UK
Publisher
Informa UK Limited
Subject
Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine
Link
https://www.tandfonline.com/doi/pdf/10.1080/00498254.2017.1323137
Reference27 articles.
1. Azaro A, Baselga J, Sepúlveda JM, et al. (2012). The oral transforming growth factor-beta (TGF-β) receptor I kinase inhibitor galunisertib plus lomustine in patients with treatment-refractory malignant glioma: the first human dose study. ASCO Annual Meeting; Chicago, IL. J Clin Oncol. Abstract Number 2042.
2. Mass Balance Studies, with a Focus on Anticancer Drugs
3. Human mass balance study of the novel anticancer agent ixabepilone using accelerator mass spectrometry
4. Trabectedin (YondelisTM, formerly ET-743), a mass balance study in patients with advanced cancer
5. Determination of Human Hepatocyte Intrinsic Clearance for Slowly Metabolized Compounds: Comparison of a Primary Hepatocyte/Stromal Cell Co-culture with Plated Primary Hepatocytes and HepaRG
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