New insights in the metabolism of oxybutynin: evidence of N-oxidation of propargylamine moiety and rearrangement to enaminoketone
Author:
Affiliation:
1. Department of Pharmaceutical Sciences, Laboratory of Pharmaceutical Analysis, University of Eastern Piedmont, Novara, Italy and
2. Department of Neuroscience, Psychology, Drug Research and Child's Health, University of Florence, Firenze, Italy
Publisher
Informa UK Limited
Subject
Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine
Link
https://www.tandfonline.com/doi/pdf/10.1080/00498254.2017.1342288
Reference14 articles.
1. New insights in oxybutynin chemical stability: Identification in transdermal patches of a new impurity arising from oxybutynin N-oxide rearrangement
2. The pharmacokinetics of oxybutynin in man
3. Measurement of oxybutynin and its N-desethyl metabolite in plasma, and its application to pharmacokinetic studies in young, elderly and frail elderly volunteers
4. Metabolism of oxybutynin: Establishment of desethyloxybutynin and oxybutyninN-oxide formation in rat liver preparations using deuterium substitution and gas chromatographic mass spectrometric analysis
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