Comprehensive evaluation of liver microsomal cytochrome P450 3A (CYP3A) inhibition: comparison of cynomolgus monkey and human
Author:
Affiliation:
1. Bristol-Myers Squibb, Wallingford, CT, USA,
2. Pfizer Global Research and Development, Groton, CT, USA, and
3. Biocon Bristol-Myers Squibb Research and Development Center, Syngene International Limited, Bangalore, Karnataka, India
Publisher
Informa UK Limited
Subject
Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine
Link
https://www.tandfonline.com/doi/pdf/10.1080/00498254.2016.1203042
Reference49 articles.
1. A Comparison of Pharmacokinetics between Humans and Monkeys
2. Time-Dependent Inactivation of P450 3A4 by Raloxifene: Identification of Cys239 as the Site of Apoprotein Alkylation1
3. Determining the best animal model for human cytochrome P450 activities: a comparison of mouse, rat, rabbit, dog, micropig, monkey and man
4. Pharmacokinetics/Pharmacodynamics Model-Supported Early Drug Development
5. Evaluation of Cynomolgus Monkeys for the Identification of Endogenous Biomarkers for Hepatic Transporter Inhibition and as a Translatable Model to Predict Pharmacokinetic Interactions with Statins in Humans
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