Direct and quantitative evaluation of the human CYP3A4 contribution (fm) to drug clearance using the in vitro SILENSOMES model-Reference-Cited by-同舟云学术

Direct and quantitative evaluation of the human CYP3A4 contribution (fm) to drug clearance using the in vitro SILENSOMES model

Published:2016-08-03 Issue:7 Volume:47 Page:562-575
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Parmentier Yannick¹,Pothier Corinne¹,Delmas Audrey¹,Caradec Fabrice¹,Trancart Marie-Michèle²,Guillet Fabrice²,Bouaita Belkacem³,Chesne Christophe³,Brian Houston J.⁴,Walther Bernard¹

Affiliation:

1. Biopharmaceutical Research Department, Technologie Servier, Orléans Cedex, France,

2. Eurosafe, Saint-Grégoire, France,

3. Biopredic International, Rennes, France, and

4. Manchester University, Manchester, UK

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/00498254.2016.1208854

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1. Inhibition of the sulfoxidation of omeprazole by ketoconazole in poor and extensive metabolizers of S-mephenytoin*

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3. Progress Curve Mechanistic Modeling Approach for Assessing Time-Dependent Inhibition of CYP3A4

4. Use of cDNA-Expressed Human Cytochrome P450 Enzymes to Study Potential Drug-Drug Interactions

5. Are there differences in the catalytic activity per unit enzyme of recombinantly expressed and human liver microsomal cytochrome P450 2C9? A systematic investigation into inter-system extrapolation factors

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