In vitro metabolism of the anti-inflammatory clerodane diterpenoid polyandric acid A and its hydrolysis product by human liver microsomes and recombinant cytochrome P450 and UDP-glucuronosyltransferase enzymes-Reference-Cited by-同舟云学术

In vitro metabolism of the anti-inflammatory clerodane diterpenoid polyandric acid A and its hydrolysis product by human liver microsomes and recombinant cytochrome P450 and UDP-glucuronosyltransferase enzymes

Published:2016-07-14 Issue:6 Volume:47 Page:461-469
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Bendikov Matthew Y.¹²,Miners John O.¹³,Simpson Bradley S.³⁴,Elliot David J.⁵,Semple Susan J.⁴,Claudie David J.⁶,McKinnon Ross A.³,Gillam Elizabeth M. J.⁷,Sykes Matthew J.²

Affiliation:

1. Department of Clinical Pharmacology, School of Medicine, Flinders University, Adelaide, Australia,

2. Centre for Drug Discovery and Development, Sansom Institute for Health Research, University of South Australia, Adelaide, Australia,

3. Flinders Centre for Innovation in Cancer, School of Medicine, Flinders University, Adelaide, Australia,

4. Quality Use of Medicines and Pharmacy Research Centre, Sansom Institute for Health Research, University of South Australia, Adelaide, Australia,

5. Department of Clinical Pharmacology, Flinders Medical Centre, Adelaide, Australia,

6. Chuulangun Aboriginal Corporation, Cairns Mail Centre, Cairns, Australia, and

7. School of Chemistry and Molecular Biosciences, the University of Queensland, Brisbane, Australia

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/00498254.2016.1203041

Reference51 articles.

1. Bioactivation of 4-Ipomeanol by CYP4B1: Adduct Characterization and Evidence for an Enedial Intermediate

2. Scaling Factors for the Extrapolation of In Vivo Metabolic Drug Clearance From In Vitro Data: Reaching a Consensus on Values of Human Micro-somal Protein and Hepatocellularity Per Gram of Liver

3. In vitro-in vivo correlations for drugs eliminated by glucuronidation: Investigations with the model substrate zidovudine

4. S-Naproxen and desmethylnaproxen glucuronidation by human liver microsomes and recombinant human UDP-glucuronosyltransferases (UGT): role of UGT2B7 in the elimination of naproxen

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Evidence-based strategies for the characterisation of human drug and chemical glucuronidation in vitro and UDP-glucuronosyltransferase reaction phenotyping;Pharmacology & Therapeutics;2021-02