Identification of cytochrome P450s involved in the metabolism of 6-benzyl-1-benzyloxymethyl-5-iodouracil (W-1) using human recombinant enzymes and rat liver microsomes in vitro-Reference-Cited by-同舟云学术

Identification of cytochrome P450s involved in the metabolism of 6-benzyl-1-benzyloxymethyl-5-iodouracil (W-1) using human recombinant enzymes and rat liver microsomes in vitro

Published:2017-01-12 Issue:8 Volume:47 Page:667-672
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Lu Ying-Yuan¹,Cheng Hai-Xu¹,Wang Xin¹,Wang Xiao-Wei²,Liu Jun-Yi²,Li Pu¹,Lou Ya-Qing¹,Li Jun³,Lu Chuang⁴,Zhang Guo-Liang¹

Affiliation:

1. Department of Pharmacology, School of Basic Medical Science, Beijing (Peking) University, Beijing, PR China,

2. Department of Chemical Biology, School of Pharmaceutical Sciences, Beijing (Peking) University, Beijing, PR China,

3. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Beijing (Peking) University, Beijing, PR China, and

4. Department of Drug Metabolism & Pharmacokinetics, Biogen, Cambridge, MA, USA

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/00498254.2016.1217365

Reference37 articles.

1. Studies on metabolites and metabolic pathways of bulleyaconitine A in rat liver microsomes using LC-MSncombined with specific inhibitors

2. Selection and characterization of viruses resistant to the dual acting pyrimidinedione entry and non-nucleoside reverse transcriptase inhibitor IQP-0410

3. Non-Nucleoside HIV-1 Reverse Transcriptase (RT) Inhibitors: Past, Present, and Future Perspectives

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