Pirfenidone 5-hydroxylation is mainly catalysed by CYP1A2 and partly catalysed by CYP2C19 and CYP2D6 in the human liver-Reference-Cited by-同舟云学术

Pirfenidone 5-hydroxylation is mainly catalysed by CYP1A2 and partly catalysed by CYP2C19 and CYP2D6 in the human liver

Published:2021-11-30 Issue:12 Volume:51 Page:1352-1359
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Zhang Yongjie¹²,Sato Rei³,Fukami Tatsuki²³,Nakano Masataka²³,Nakajima Miki²³

Affiliation:

1. Clinical Pharmacokinetics Laboratory, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China

2. WPI Nano Life Science Institute, Kanazawa University, Kanazawa, Japan

3. Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/00498254.2021.2007553

Reference19 articles.

1. Expression of Hepatic Drug-Metabolizing Cytochrome P450 Enzymes and Their Intercorrelations: A Meta-Analysis

2. Identification of enzymes responsible for dantrolene metabolism in the human liver: A clue to uncover the cause of liver injury

3. Long-term safety of pirfenidone: results of the prospective, observational PASSPORT study

4. Xenobiotic-metabolizing human cells as tools for pharmacological and toxicological research

5. European Medicines Agency. 2017. Esbriet (Pirfenidone): Summary of Product Characteristics. www.ema.europa.eu/documents/product-information/esbriet-epar-product-information_eu.pdf.

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