Characterization of the methemoglobin forming metabolites of benzocaine and lidocaine
Author:
Affiliation:
1. Division of Applied Regulatory Science, FDA/CDER/OTS/OCP, Silver Spring, MD, USA and
2. Division of Pharmaceutical Analysis, FDA/CDER/OPS/OTR, Silver Spring, MD, USA
Publisher
Informa UK Limited
Subject
Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine
Link
https://www.tandfonline.com/doi/pdf/10.1080/00498254.2016.1196402
Reference25 articles.
1. Occupational Methaemoglobinaemia
2. Risk of Topical Anesthetic–Induced Methemoglobinemia
3. Drug-Induced Methaemoglobinaemia Treatment Issues
4. Bioactivation of benzocaine to a methaemoglobin-forming metabolite by rat and human microsomes in vitro
5. Chemical and biological factors affecting mutagen potency
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