Simulation of human plasma concentration–time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite using humanized chimeric mice and semi-physiological pharmacokinetic modeling-Reference-Cited by-同舟云学术

Simulation of human plasma concentration–time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite using humanized chimeric mice and semi-physiological pharmacokinetic modeling

Published:2016-07-07 Issue:5 Volume:47 Page:382-393
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Kamimura Hidetaka¹²,Ito Satoshi¹,Chijiwa Hiroyuki³,Okuzono Takeshi³,Ishiguro Tomohiro³,Yamamoto Yosuke³,Nishinoaki Sho³,Ninomiya Shin-Ichi¹,Mitsui Marina⁴,Kalgutkar Amit S.⁵,Yamazaki Hiroshi⁴,Suemizu Hiroshi²

Affiliation:

1. Drug Development Solutions Division, Sekisui Medical Co., Ltd., Tokyo, Japan,

2. Laboratory Animal Research Department, Central Institute for Experimental Animals, Kawasaki, Kanagawa, Japan,

3. Drug Development Solutions Division, Sekisui Medical Co., Ltd., Ibaraki, Japan,

4. Showa Pharmaceutical University, Machida, Tokyo, Japan, and

5. Medicinal Sciences, Pfizer Inc., Cambridge, MA, USA

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Link

https://tandfonline.com/doi/pdf/10.1080/00498254.2016.1199063

Reference43 articles.

1. Predicting Circulating Human Metabolites: How Good Are We?

2. Application of Chimeric Mice with Humanized Liver for Study of Human-Specific Drug Metabolism

3. The microsomal demethylation of N,N-dimethylbenzamides

4. Assessment of Three Human in Vitro Systems in the Generation of Major Human Excretory and Circulating Metabolites

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