Danazol increases the oral bioavailability of midazolam by inactivation of hepatic and intestinal CYP3A in rats-Reference-Cited by-同舟云学术

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Danazol increases the oral bioavailability of midazolam by inactivation of hepatic and intestinal CYP3A in rats

Published:2023-05-04 Issue:5 Volume:53 Page:421-428
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Fukuno Shuhei¹^ORCID,Nagai Katsuhito¹^ORCID,Kurotobi Akemi¹,Sahori Yuki¹,Nakagawa Ryo¹,Nomura Rena¹,Ito Takuya²^ORCID,Konishi Hiroki¹^ORCID

Affiliation:

1. Laboratory of Clinical Pharmacy and Therapeutics, Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi, Japan

2. Laboratory of Natural Medicines, Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi, Japan

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/00498254.2023.2253314

Reference28 articles.

1. Intestinal Expression and Metabolic Activity of the CYP3A Subfamily in Female Rats

2. Actions of danazol in vivo on cytochrome P-450 and steroidogenic enzymes in rat testis and liver microsomal preparations

3. Mechanism-based inhibition of human cytochrome P4503A4 by domperidone

4. Cytochrome P450 probe substrate metabolism kinetics in Sprague Dawley rats

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