An integrated analytical strategy to decipher the metabolic profile of alkaloids in Compound Kushen injection based on UHPLC-ESI-QTOF/MS<sup>E</sup>-Reference-Cited by-同舟云学术

An integrated analytical strategy to decipher the metabolic profile of alkaloids in Compound Kushen injection based on UHPLC-ESI-QTOF/MS^E

Published:2023-04-03 Issue:4 Volume:53 Page:248-259
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Zhang Li¹,Li Ruijuan²,Zheng Ting²,Wu Huan²³^ORCID,Yin Yanyan¹

Affiliation:

1. Department of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China

2. Key Laboratory of Xin’an Medicine, Ministry of Education, Anhui University of Chinese Medicine, Hefei, China

3. Anhui Province Key Laboratory of Research and Development of Chinese Medicine & Anhui Province Key Laboratory of Chinese Medicinal Formula, Anhui University of Chinese Medicine, Hefei, China

Funder

National Natural Science Foundation of China

Natural Science Fund of Anhui Provincial Department of Education

Natural Science Fund of Anhui Province

Research Fund of Anhui Institute of translational medicine

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/00498254.2023.2227976

Reference36 articles.

1. High-resolution chromatography/time-of-flight MSE with in silico data mining is an information-rich approach to reactive metabolite screening

2. MSE with mass defect filtering forin vitro andin vivo metabolite identification

3. Fragmentation pathways of drugs of abuse and their metabolites based on QTOF MS/MS and MSE accurate-mass spectra

4. Enhanced metabolite identification with MSE and a semi-automated software for structural elucidation

5. Chemical and metabolic analysis of Achyranthes bidentate saponins with intestinal microflora-mediated biotransformation by ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry coupled with metabolism platform

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