Cytochrome P450 1A2 and 2C enzymes autoinduced by omeprazole in dog hepatocytes and human HepaRG and HepaSH cells are involved in omeprazole 5-hydroxylation and sulfoxidation-Reference-Cited by-同舟云学术

Cytochrome P450 1A2 and 2C enzymes autoinduced by omeprazole in dog hepatocytes and human HepaRG and HepaSH cells are involved in omeprazole 5-hydroxylation and sulfoxidation

Published:2023-07-03 Issue:6-7 Volume:53 Page:465-473
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Uno Yasuhiro¹^ORCID,Uehara Shotaro²^ORCID,Ushirozako Genki¹,Murayama Norie³,Suemizu Hiroshi²^ORCID,Yamazaki Hiroshi³^ORCID

Affiliation:

1. Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan

2. Department of Applied Research for Laboratory Animals, Central Institute for Experimental Animals, Kawasaki, Japan

3. Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Japan

Funder

Japan Society for the Promotion of Science Grant-in-Aid

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/00498254.2023.2266840

Reference31 articles.

1. Stereoselective metabolism of omeprazole by human cytochrome P450 enzymes;Abelo A;Drug Metab Dispos,2000

2. Stable Expression, Activity, and Inducibility of Cytochromes P450 in Differentiated HepaRG Cells

3. Combined phenotypic assessment of cytochrome P450 1A2, 2C9, 2C19, 2D6, and 3A, N-acetyltransferase-2, and xanthine oxidase activities with the “Cooperstown 5+1 cocktail”

4. Omeprazole and lansoprazole are mixed inducers of CYP1A and CYP3A in human hepatocytes in primary culture;Curi-Pedrosa R;J Pharmacol Exp Ther,1994

5. Omeprazole, an inducer of human CYP1A1 and 1A2, is not a ligand for the Ah receptor

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