Discovery and pharmacological effects of a novel GPR142 antagonist-Reference-Cited by-同舟云学术

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Discovery and pharmacological effects of a novel GPR142 antagonist

Published:2016-11-03 Issue:3 Volume:37 Page:290-296
ISSN:1079-9893
Container-title:Journal of Receptors and Signal Transduction
language:en
Short-container-title:Journal of Receptors and Signal Transduction

Author:

Murakoshi Michiko¹,Kuwabara Harumi²,Nagasaki Miyuki³,Xiong Yu Mei⁴,Reagan Jeff D.⁴,Maeda Hiroaki⁵,Nara Futoshi³

Affiliation:

1. Biological Research Department, Daiichi Sankyo RD Novare Co. Ltd., Tokyo, Japan;

2. Pain & Neuroscience Laboratories, Research Function, R&D Division, Daiichi Sankyo Co. Ltd., Tokyo, Japan;

3. Biologics & Immuno-Oncology Laboratories Research Function, R&D Division, Daiichi Sankyo Co. Ltd., Tokyo, Japan;

4. Department of Cardio-Metabolic Disorders, Amgen, Inc., South San Francisco, CA, USA;

5. Immunology & Inflammatory Disease Field, Asubio Pharma Co. Ltd., Kobe, Japan

Publisher

Informa UK Limited

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://www.tandfonline.com/doi/pdf/10.1080/10799893.2016.1247861

Reference24 articles.

1. Characterisation and differential expression of two very closely related G-protein-coupled receptors, GPR139 and GPR142, in mouse tissue and during mouse development

2. GPR139, an Orphan Receptor Highly Enriched in the Habenula and Septum, Is Activated by the Essential Amino Acids l-Tryptophan and l-Phenylalanine

3. Discovery and optimization of a novel series of GPR142 agonists for the treatment of type 2 diabetes mellitus

4. Xiong Y, Motani A, Reagan J, et al. manuscript is in preparation.

5. Tryptophan and the immune response

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