Genotoxicity evaluation of self-assembled-micelle inhibitory RNA-targeting amphiregulin (SAMiRNA-AREG), a novel siRNA nanoparticle for the treatment of fibrotic disease-Reference-Cited by-同舟云学术

Genotoxicity evaluation of self-assembled-micelle inhibitory RNA-targeting amphiregulin (SAMiRNA-AREG), a novel siRNA nanoparticle for the treatment of fibrotic disease

Published:2021-04-27 Issue: Volume: Page:1-7
ISSN:0148-0545
Container-title:Drug and Chemical Toxicology
language:en
Short-container-title:Drug and Chemical Toxicology

Author:

Kim Hyeon-Young¹²,Kim Tae Rim³,Kim Sung-Hwan¹,Kim In-Hyeon¹²,Ko Youngho³,Yun Sungil³,Lee In-Chul⁴,Park Han-Oh³,Kim Jong-Choon²

Affiliation:

1. Jeonbuk Branch Institute, Korea Institute of Toxicology, Jeongeup, Republic of Korea

2. College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea

3. siRNAgen therapeutics and Bioneer Corporation, Daejeon, Republic of Korea

4. Functional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup, Republic of Korea

Funder

Civil and Military Dual-use Technology Program

Korea Drug Development Fund

Ministry of Trade, Industry, and Energy

Ministry of Health and Welfare

Bioneer Corporation and siRNAgen Therapeutics Research Fund

Publisher

Informa UK Limited

Subject

Chemical Health and Safety,Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health,Pharmacology,Toxicology,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/01480545.2021.1908003

Reference45 articles.

1. Antimutagenic evaluation of vitamins B1, B6 and B12 in vitro and in vivo, with the Ames test

2. Is there a continuing role for the intraperitoneal injection route of exposure in short-term rodent genotoxicity assays?

3. OSWG Recommendations for Genotoxicity Testing of Novel Oligonucleotide-Based Therapeutics

4. Micronucleus assay in aquatic animals

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