Use of a non-hepatic cell line highlights limitations associated with cell-based assessment of metabolically induced toxicity-Reference-Cited by-同舟云学术

Use of a non-hepatic cell line highlights limitations associated with cell-based assessment of metabolically induced toxicity

Published:2019-03-18 Issue:6 Volume:43 Page:656-662
ISSN:0148-0545
Container-title:Drug and Chemical Toxicology
language:en
Short-container-title:Drug and Chemical Toxicology

Author:

Weyers Carli¹²,Dingle Laura M. K.²³,Wilhelmi Brendan S.³,Edkins Adrienne L.²³^ORCID,Veale Clinton G. L.⁴^ORCID

Affiliation:

1. Faculty of Pharmacy, Rhodes University, Grahamstown, South Africa;

2. Biomedical Biotechnology Research Unit, Rhodes University, Grahamstown, South Africa;

3. Department of Biochemistry and Microbiology, Rhodes University, Grahamstown, South Africa;

4. School of Chemistry and Physics, Pietermaritzburg Campus, University of KwaZulu-Natal, Scottsville, South Africa

Funder

Department of Science and Technology

National Research Foundation of South Africa

National Research Foundation

Publisher

Informa UK Limited

Subject

Chemical Health and Safety,Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health,Pharmacology,Toxicology,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/01480545.2019.1585869

Reference42 articles.

1. CYP3A4-dependent cellular response does not relate to CYP3A4-catalysed metabolites of C-1748 and C-1305 acridine antitumor agents in HepG2 cells

2. Mediation of Arachidonic Acid Metabolite(s) Produced by Endothelial Cytochrome P-450 3A4 in Monkey Arterial Relaxation.

3. New Technologies and Screening Strategies for Hepatotoxicity: Use of In Vitro Models

4. FLUORESCENCE-BASED ASSAYS FOR SCREENING NINE CYTOCHROME P450 (P450) ACTIVITIES IN INTACT CELLS EXPRESSING INDIVIDUAL HUMAN P450 ENZYMES

5. Human Hepatocytes with Drug Metabolic Function Induced from Fibroblasts by Lineage Reprogramming